Choroid Plexus Apocrine Secretion Shapes CSF Proteome During Mouse Brain Development

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development

The choroid plexus (ChP) regulates cerebrospinal fluid (CSF) composition, providing essential molecular cues for brain development; yet, embryonic ChP secretory mechanisms remain poorly defined. Here we identify apocrine secretion by embryonic ChP epithelial cells as a key regulator of the CSF proteome and neurodevelopment in male and female mice. We demonstrate that the activation of serotonergic 5-HT2C receptors (by WAY-161503) triggers sustai…

Choroid Plexus Drives CSF Protein Changes in Development

In a groundbreaking study published in Nature Neuroscience, a multidisciplinary team of researchers sheds new light on the dynamic interplay between the choroid plexus and cerebrospinal fluid (CSF) composition during critical phases of mouse brain development. This research revolutionizes our understanding of how the brain’s internal environment is meticulously shaped, revealing previously unknown mechanisms of protein secretion that may have fa…