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Transferability of European-Derived Alzheimer’s Disease Polygenic Risk Scores Across Multiancestry Populations

YALE UNIVERSITY, JUN 17 – Yale researchers identified protein changes at the myelin-axon interface that may disrupt nerve signaling in Alzheimer's, with findings published in Nature Neuroscience.

Summary by Nature
A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations o…

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June 18, 2025 Niigata University A research group led by Associate Professor Masataka Kikuchi and Professor Ken Ikeuchi of the Department of Gene Function Analysis at the Niigata University Brain Research Institute, together with Professor Jean-Charles Lambert of the Institut Pasteur de Lille in France, examined the influence of genetic risk for Alzheimer's disease in 28 countries.

·Chiyoda, Japan
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The Laboratory of Neurophysiology and Behavior of the Faculty of Medicine of Ciudad Real uses, for the first time, the novel technique ‘MALDI imagery’

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knowablemagazine.org broke the news in on Tuesday, June 17, 2025.
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