Transferability of European-Derived Alzheimer’s Disease Polygenic Risk Scores Across Multiancestry Populations
YALE UNIVERSITY, JUN 17 – Yale researchers identified protein changes at the myelin-axon interface that may disrupt nerve signaling in Alzheimer's, with findings published in Nature Neuroscience.
6 Articles
6 Articles
June 18, 2025 Niigata University A research group led by Associate Professor Masataka Kikuchi and Professor Ken Ikeuchi of the Department of Gene Function Analysis at the Niigata University Brain Research Institute, together with Professor Jean-Charles Lambert of the Institut Pasteur de Lille in France, examined the influence of genetic risk for Alzheimer's disease in 28 countries.
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations
A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations o…
Myelin sheath protein changes linked to impaired nerve signaling in Alzheimer's disease
The disruption of axons—the thread-like part of nerve cells that transmits electrical signals—is associated with Alzheimer's disease. One way axonal function may be hindered is through damage to the myelin sheath, a fatty coating that wraps around axons. Similar to the plastic or rubber used to insulate a cable, the myelin sheath allows neurons to quickly communicate with one another. When the structure is impaired, so is the conduction of elect…
Genetics of PLCG2 expression and splicing relative to Alzheimer’s disease risk
Background PLCG2 is associated with the risk of Alzheimer’s disease (AD) through a rare missense polymorphism, rs72824905 (P522R) as well as a common variant, rs12445675, within a long non-coding RNA adjacent to PLCG2. Elucidating the impact of genetics on PLCG2 express...
The Laboratory of Neurophysiology and Behavior of the Faculty of Medicine of Ciudad Real uses, for the first time, the novel technique ‘MALDI imagery’
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