AI used to design immune-safe 'zinc finger' proteins for gene therapy

Active learning-assisted directed evolution

Directed evolution (DE) is a powerful tool to optimize protein fitness for a specific application. However, DE can be inefficient when mutations exhibit non-additive, or epistatic, behavior. Here, we present Active Learning-assisted Directed Evolution (ALDE), an iterative machine learning-assisted DE workflow that leverages uncertainty quantification to explore the search space of proteins more efficiently than current DE methods. We apply ALDE …

Taysha Gene Therapies (NASDAQ:TSHA) Given "Buy" Rating at Needham & Company LLC

Needham & Company LLC reaffirmed a "buy" rating and set a $8.00 target price (up from $6.00) on shares of Taysha Gene Therapies in a report on Monday.

AI used to design immune-safe 'zinc finger' proteins for gene therapy

Machine learning models have seeped into the fabric of our lives, from curating playlists to explaining hard concepts in a few seconds. Beyond convenience, state-of-the-art algorithms are finding their way into modern-day medicine as a powerful potential tool. In one such advance, published in Cell Systems, Stanford researchers are using machine learning to improve the efficacy and safety of targeted cell and gene therapies by potentially using …

'Freedom From the Need': A Pharmacist's Journey from Constant Hemophilia B Treatment to Gene Therapy

Chip Hailey, a 74-year-old pharmacist with hemophilia B, shares how gene therapy has liberated him from decades of challenging treatment and restored his independence.