Why cells need brakes: Uncovering the role of MAD1 as a guardian against cancer

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Cancer begins when in cells the genetic material undergoes mutations that lead to uncontrolled proliferation into tumors. But not all cells that have oncogenic mutations will lead to cancer, because the organism has protective mechanisms to neutralize or destroy potentially carcinogenic cells. A research published in Nature and in which Mariano Barbacid, head of the Experimental Oncology Group of the National Center for Oncological Research (CNI…