US EditionNewly Identified Group of Nerve Cells in the Brain Regulates Bodyweight
- Researchers led by Lucas Mavromatis analyzed data from over 170,000 obese adults with diabetes in the US between 2013 and 2023 to assess GLP-1 drugs and cancer risk.
- This study compared GLP-1 receptor agonists to older diabetes medications and was motivated by obesity’s rising role in cancer and the lack of medications proven to reduce this risk.
- The analysis showed a 7% lower overall risk of 14 obesity-related cancers, primarily colon and rectal cancers, among GLP-1 users, with a 16% reduction specifically in colon cancer cases.
- Women treated with GLP-1 medications showed a reduced incidence of obesity-associated cancers by 8% and a 20% decrease in overall mortality risk, whereas no notable cancer risk reduction was observed in men, based on reported hazard ratios and statistical significance.
- Although the study does not establish causation and calls for further research, these findings suggest GLP-1 medications might modestly reduce some cancer risks and death rates in patients with obesity and diabetes.
24 Articles
24 Articles
Newly identified group of nerve cells in the brain regulates bodyweight
Obesity is a global health problem that affects many people. In recent years, very promising anti-obesity drugs have been developed. Despite these successes, there are patients who do not respond to these drugs or suffer from side effects. Therefore, there is still an unmet need for therapies. Researchers have now discovered a small group of nerve cells in the hypothalamus of mouse brains that influence eating behavior and weight gain. This disc…
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Summer is finally here! The bad news is that for many of us, the New Years resolutions are a distant memory and the reality is that we still have extra weight we would like to drop before we hit the beach or the pool or the lake. The good news is that you can still do something to drop that weight – without the needles! Semaglutide – A clinically-trusted GLP-1 receptor agonist, is now available in a fast-acting oral spray. It helps reduce appeti…
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