Molecular Basis of Positional Memory in Limb Regeneration

Molecular basis of positional memory in limb regeneration

The amputation of a salamander limb triggers anterior and posterior connective tissue cells to form distinct signalling centres that together fuel regeneration1. Anterior and posterior identities are established during development and are thought to persist for the whole life in the form of positional memory2. However, the molecular basis of positional memory and whether positional memory can be altered remain unknown. Here, we identify a positi…

Fábio Martins presents Research at LAQV Webinar Series – BioSIM

Fábio Martins presented a talk in the LAQV webinar series of May 21, organized by the High Performance Computing in Molecular Modelling Research Group. In this talk, entitled “Molecular Insights into HIV-1 Integration: A Computational Study of Intasome-Nucleosome Interactions“, Fábio presented part of his work developed at BioSIM on the use of computational approaches, such as molecular docking and molecular dynamics simulations, to elucidate in…

The Lurch is famous for being able to renew limbs. But how do his cells know which side of the leg they are supposed to form? The answer is also relevant for humansThe Lurch is famous for being able to renew limbs. But how do his cells know which side of the leg they are supposed to form? The answer is also relevant for humans.

The team found the code that ensures that cells are re-formed in the right place in the body – a "breakthrough in regeneration research"