Understanding the Structure-Release Relationships of Sepineo™: molecular dynamics, physico-chemical characterization, in vitro and ex vivo permeation - Pharma Excipients

Understanding the Structure-Release Relationships of Sepineo™: molecular dynamics, physico-chemical characterization, in vitro and ex vivo permeation - Pharma Excipients

Abstract The physical and mechanical characteristics of gels are crucial in developing and manufacturing various topical therapeutic products. This study thoroughly examined the influence of pH modifications and the ionization status of diclofenac sodium, as an Active Pharmaceutical Ingredient (API), on the rheological behavior, in vitro release kinetics, and ex vivo skin permeation profiles of Sepineo gels. Further, molecular dynamic simulation…