US EditionTumor-Instructed Glutamine Synthesis in Cancer-Associated Fibroblasts Promotes Pro-Tumor Macrophages
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Tumor-Instructed Glutamine Synthesis in Cancer-Associated Fibroblasts Promotes Pro-Tumor Macrophages
Scientists found that glutamine synthesis by cancer-associated fibroblasts (CAFs) promotes the polarization of pro-tumorigenic tumor-associated macrophages (TAMs) and supports tumor growth by altering TAM composition, highlighting the pivotal role of CAFs in shaping the immunosuppressive tumor microenvironment. [Journal of Experimental Medicine] Full ArticlePress Release
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