US EditionTuesday's Daily Dose: A Federal Drug Law Is Keeping Medicare Patients Compliant and a Psychedelic May Help Smokers Quit
A pilot trial at Johns Hopkins showed a single psilocybin dose plus therapy led to 40% abstinence at six months, outperforming nicotine patches with 10% success.
- After key Inflation Reduction Act provisions took effect, researchers found cost-related medication nonadherence dropped from 8.2% to 5.7% among Medicare Part D enrollees, easing pharmacy cost barriers.
- The Inflation Reduction Act provisions aimed to lower drug costs by implementing an out-of-pocket cap and expanded subsidies, but researchers note this is only one piece of a much larger puzzle addressing patients’ medical debt, premiums, and deductibles.
- The trial assigned 82 psychiatrically healthy adult smokers 1:1 to psilocybin or nicotine patches with 13-week CBT; one-day abstinence was 90.5% versus 80%, six-month was 52.4% versus 25%, with peak blood pressure 160.2/100.9 mm and one participant treated with nitroglycerin.
- Among beneficiaries managing two or more chronic conditions, the study reported nearly 8 percentage points improvement, and psilocybin recipients were over six times likelier to stay smoke-free at six months, despite tobacco killing nearly 480,000 Americans each year.
- A larger National Institutes of Health-funded trial including a placebo arm is underway, while a pharmaceutical company expected to submit a new drug application later this year; researchers caution larger, more diverse trials are needed.
12 Articles
12 Articles
A dose of psilocybin helps smokers quit in new study
The long-running campaign against smoking could find reinforcements from the new wave of research into psychedelics.Though much of the attention around psychedelics has focused on depression and other mental health conditions, researchers believe these substances also hold the potential to transform addiction treatment.A new study makes the strongest case yet for a psychedelic drug’s impact on smoking, which remains the leading cause of preventa…
Marijuana Moment
Psilocybin Helps People Quit Cigarettes More Effectively Than Nicotine Patches Do, American Medical Association-Published Study Shows
Just one dose of psilocybin combined with therapy is associated with “significantly increased long-term abstinence” from cigarettes compared to nicotine patches, according to a new study published by the American Medical Association (AMA) that indicates the psychedelic “holds potential in the treatment of tobacco use disorder.” Researchers at Johns Hopkins University School of Medicine and the University of Alabama at Birmingham conducted the st…
High-Dose Psychedelic Beats Nicotine Patches for Smoking Cessation
(MedPage Today) -- A single high-strength dose of psilocybin was more effective than nicotine patches for helping smokers quit, a pilot randomized trial showed. When added to cognitive behavioral therapy (CBT), 40.5% of participants who received...
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