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'Transformational' new drug could stop breast cancer tumours before they grow, trial finds
Researchers presented results from the Serena-6 trial in 2025, showing that camizestrant delays breast cancer progression worldwide.
The trial targeted patients with hormone receptor-positive, HER2-negative advanced breast cancer, where mutations in the ESR1 gene cause treatment resistance.
Scientists used blood tests to detect circulating tumour DNA early, allowing therapy switches before cancer growth, improving patient outcomes significantly.
Camizestrant extended the time patients lived without their cancer worsening or dying by 56%, with a median duration of 16 months compared to 9 months for standard treatments.
These findings represent a pivotal advance in personalized breast cancer care, potentially delaying chemotherapy and improving precision treatment strategies globally.