US EditionParasites Trigger Epithelial Cell Crosstalk to Drive Gut–Brain Signalling
UCSF researchers identified a two-phase acetylcholine release by tuft cells that triggers serotonin release, causing appetite loss during parasitic infection, explaining delayed sickness onset.
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5 Articles
Eldiario.es
elDiarioARA group of researchers have described the mechanism by which intestinal parasites activate the signal that comes from the immune system to the brain, which opens up new possible ways to treat intestinal or food diseases more specificallyHemeroteca - Discover how pancreatic cancer is allied with our neurons to spread The team of David Julius, who won the Nobel Prize in Medicine in 2021 for identifying the mechanisms by which we perceive temperatu…
Parasites trigger epithelial cell crosstalk to drive gut–brain signalling
Parasitic infections modulate both immune and sensory responses, but how these systems collaborate to elicit protective behaviours remains incompletely understood. The gut epithelium contains specialized sensory cells that detect pathogens and irritants. These include cholinergic tuft cells, which sense parasites and initiate type 2 immune responses1–3, as well as serotonergic enterochromaffin (EC) cells, which detect irritants and communicate w…
Parasites Prompt Gut-Brain Communication to Trigger Appetite Loss
Anyone who has weathered a bad stomach bug knows the feeling: a loss of appetite that sets in and lingers, even after the initial illness. For the millions of people around the world who are chronically infected with parasitic worms, the same thing happens. But scientists have long puzzled over exactly why. Researchers at UC San Francisco now report that they have traced the molecular pathway that connects the gut immune system to the brain duri…
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