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Russian Claims mRNA Cancer Vaccine 'Enteromix' Achieves 100% Efficacy, Awaits Health Ministry Sign-Off

EnteroMix, a personalized mRNA vaccine targeting colorectal cancer, showed 100% safety and significant tumor reduction in 48 volunteer Phase I trials, pending Russian health approval.

  • On Saturday, FMBA head Veronika Skvortsova announced EnteroMix, Russia's mRNA-based cancer vaccine by National Medical Research Radiological Centre and Engelhardt Institute, is ready for use and awaiting approval at the Eastern Economic Forum.
  • After several years of work, developers focused three years on preclinical studies that confirmed safety and created personalised mRNA based on each patient's RNA, FMBA head Veronika Skvortsova said.
  • Researchers reported tumour reductions of 60% to 80% in preclinical animal models and early human data, while the Phase I trial with around 48 volunteers showed very low toxicity and no serious side effects.
  • Health authorities must grant approval before EnteroMix can reach patients, and experts urge larger Phase II and Phase III clinical trials to validate efficacy despite promising early safety data.
  • Globally, developers in Britain and the United States are also racing to develop cancer vaccines; EnteroMix employs a novel approach using four re-engineered harmless viruses while BioNTech, Moderna, and Merck pursue vaccines targeting glioblastoma and ocular melanoma.
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RTVI broke the news in Moscow, Russian Federation on Saturday, September 6, 2025.
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