US EditionNobel Prize in Medicine Goes to 3 Scientists for Work on Human Immune System
The 2025 Nobel Prize in Medicine honors three scientists for key discoveries about regulatory T cells and the Foxp3 gene, advancing understanding of immune system regulation.
- On October 6, 2025, the Nobel Committee awarded Mary E. Brunkow, Fred Ramsdell and Dr. Shimon Sakaguchi for discoveries on peripheral immune tolerance, announced at the Karolinska Institute in Stockholm.
- Dr. Shimon Sakaguchi first identified regulatory T cells in 1995, and in 2001 Mary E. Brunkow and Fred Ramsdell linked a Foxp3 gene mutation to a rare autoimmune disease.
- Dr. Shimon Sakaguchi said at a news conference, `It was a nice surprise,` and Mary E. Brunkow learned early this morning from an AP photographer after missing a call she thought was spam.
- The Nobel Committee noted the three laureates will share 11 million Swedish kronor, and Olle Kämpe said their discoveries are decisive for understanding autoimmune diseases and treatment hopes.
- The mechanism positions the work as foundational by showing the Foxp3 gene controls development of regulatory T cells that curb overreactive T cells, opening a new field for autoimmune diseases, the Karolinska Institute said.
33 Articles
33 Articles
Le Parisien
La LibreOn an excursion to Idaho, Dr. Fred Ramsdell received yesterday morning the Nobel Prize in Medicine alongside another American and a Japanese for their work on how the body controls the immune system.
Egypt is the venue for the start of indirect negotiations between Israel and Hamas, aimed at achieving a ceasefire. The French prime minister resigned just four weeks after taking office and amid a political crisis in the country. And the Nobel Prize in Medicine was awarded to three scientists who discovered how the immune system avoids attacking its own body. Bertha Ramos has the details in El Minuto Internacional. --reporter pkg-as follows-- I…
What if we could control the body's immune response? This year's Nobel Prize winners lay the foundation for new treatment therapies - from autoimmune diseases to cancer.[more]]>
The NRC science editors update you on the Nobel Prize for Medicine, which this year goes to fundamental research on the immune system. Niki Korteweg and Sander Voormolen discuss this discovery and its impact on clinical practice.
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