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The end of the genetic paradigm of cancer

Summary by PLOS
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that questions the somatic mutation theory (SMT), and presents theories based on gene regulatory networks and tissue fields that help explain inconsistencies in the data.

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The end of the genetic paradigm of cancer

Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that questions the somatic mutation theory (SMT), and presents theories based on gene regulatory networks and tissue fields that help explain inconsistencies in the data.

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PLOS broke the news in on Thursday, March 27, 2025.
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