Targeting the ER Stress Sensor IRE1 Protects the Liver from Fibrosis through the Downregulation of the Proteostasis Factor P4HB/PDIA1
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Targeting the ER Stress Sensor IRE1 Protects the Liver from Fibrosis through the Downregulation of the Proteostasis Factor P4HB/PDIA1
Researchers investigated the possible contribution of the unfolded protein response UPR, the main adaptive pathway that monitored and adjusted protein production capacity at the ER, to collagen biogenesis and liver disease. [Hepatology] Full ArticleGraphical Abstract
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