US EditionSuppressing NEK2 may reverse vascular remodeling in PAH: Study
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Suppressing NEK2 may reverse vascular remodeling in PAH: Study
Reducing the levels of the protein NEK2 in the pulmonary arteries lessened disease-driving changes in blood vessels and the heart of a rat model of pulmonary arterial hypertension (PAH) due to congenital heart disease (CHD). The effects were tied to a modulation of the NF-kB pathway involved in vascular remodeling, a set of changes in blood vessels’ arrangement and structure that underlies PAH, the study found. “Targeting NEK2 may be an effectiv…
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