AI-Powered Microscope Predicts and Tracks Protein Aggregation Linked to Brain Diseases

AI-powered microscope predicts and tracks protein aggregation linked to brain diseases

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are destined to form harmful aggregates don't look any different than normal proteins.

Mitochondrial protein misfolding found to kill pancreatic cells in type 2 diabetes

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

Misfolded proteins accumulate in mitochondria of patients with type 2 diabetes, study finds

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

Misfolded Proteins in Mitochondria Linked to Type 2 Diabetes

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

Misfolded Proteins Accumulate in the Mitochondria of Patients with Type 2 Diabetes

In a study published in Nature Metabolism, researchers at the University of Michigan found that mitochondria also accumulate misfolded proteins, which kills β-cells.

LONP1 Regulation of Mitochondrial Protein Folding Provides Insight into Beta Cell Failure in Type 2 Diabetes

Scientists showed a robust accumulation of misfolded proteins in the mitochondria of human pancreatic islets from patients with T2D and elucidate its impact on β cell viability through the mitochondrial matrix protease LONP1. [Nature Metabolism] Full Article