Molecular Stress Makes Old Neurons Vulnerable to Neurodegenerative Diseases

Molecular stress makes old neurons vulnerable to neurodegenerative diseases

As the global population ages, the risk of developing neurodegenerative diseases such as dementia, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) continues to rise. But the molecular mechanisms behind the deterioration of brain cells have remained elusive.

Molecular stress in old neurons increases susceptibility to neurodegenerative diseases, study finds

As the global population ages, the risk of developing neurodegenerative diseases such as dementia, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) continues to rise. But the molecular mechanisms behind the deterioration of brain cells have remained elusive.

Diminished Stress Response in Aging Neurons Linked to Neurodegeneration

As people age, their risk of developing neurodegenerative disorders like dementia, Alzheimer’s disease, and Parkinson’s disease increases. A new study from scientists at the University of California, San Diego (UCSD), helps elucidate some of the molecular mechanisms behind why brain cells deteriorate with age. Specifically, they found that old neurons have dysregulated RNA metabolism that dampens their stress response and makes them susceptible …

Chronic sleep problems linked to higher dementia risk in older adults

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life New research provides insight into the relationship between sleep and neurodegenerative diseases and whether disrupted sleep is an early sign of neurodegeneration or an increased likelihood of developing dementia at a later stage. Scientists at the UK DRI at Cardiff and the U.S. National Institutes of Health (NIH)…

Molecular Stress in Old Neurons Increases Susceptibility to Neurodegenerative Diseases, Study Finds

As the global population ages, the risk of developing neurodegenerative diseases such as dementia, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) continues to rise. But the molecular mechanisms behind the deterioration of brain cells have remained elusive. Now, a new study by University of California San Diego School of Medicine researchers has found that old neurons have unique defects resulting from molecular…

Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease

Alzheimer’s disease (AD), a multifactorial neurodegenerative disorder, is characterized by metabolic deficiency, neuroinflammation, and synaptic impairment. Cerebral energy homeostasis is regulated by the astrocyte-neuron metabolic coupling through key metabolites such as lactate, glutamate, a...