US EditionStabilizing bonds in FVIII clotting protein may thwart hemophilia...
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Stabilizing bonds in FVIII clotting protein may thwart hemophilia...
The blood-clotting protein factor VIII (FVIII) that’s missing or faulty in people with hemophilia A is flexible and adopts multiple shapes, some of which favor the binding of neutralizing antibodies that can reduce the effectiveness of FVIII replacement therapies, researchers have learned. “This helps explain why some people develop resistance to treatment and opens the door to designing more stable forms of FVIII that are less likely to be targ…
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