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First Human West Nile Virus Case Confirmed in Illinois

  • Federal health officials have verified the initial human case of West Nile virus in Illinois for 2025, involving a hospitalized resident from Wayne County in the southern part of the state.
  • This early-season illness represents the earliest confirmed human West Nile virus infection in Illinois since 2016 and comes after mosquitoes testing positive were identified in 19 counties starting May 9.
  • West Nile virus transmits through Culex mosquito bites, which become carriers by feeding on infected birds, and it poses highest risk to people over 65 or with weakened immune systems.
  • Last year, Illinois reported 69 human cases and 13 deaths, the most fatal cases since 2018, and IDPH Director Dr. Sameer Vohra urged all Illinoisans to 'Fight the Bite' by taking precautions.
  • Health officials warn residents statewide to protect against mosquito bites as most infections cause mild symptoms, but severe illness can affect the brain or cause paralysis in rare cases.
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NBC Chicago broke the news in Chicago, United States on Tuesday, June 24, 2025.
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