JCI Therapeutic B Cell Depletion Identifies Immunoregulatory Networks

JCI Therapeutic B cell depletion identifies immunoregulatory networks

B cell depletion is a highly effective therapy in multiple sclerosis (MS), reducing inflammation and restoring immune balance. In this issue of the JCI, Wei et al. used single-cell RNA-Seq and flow cytometry, identifying the comprehensive effects of B cell depletion on the immune response, including an increase in antiinflammatory cerebrospinal fluid macrophages and elevated TNF-α expression by peripheral CD16+ monocytes. The authors also detect…

Signaling molecules impair growth of myelin-making brain cells

Pro-inflammatory signaling molecules that have been implicated in multiple sclerosis (MS) cause problems with the growth and development of myelin-making cells in the brain, according to a study done in […] The post Signaling molecules impair growth of myelin-making brain cells appeared first on Multiple Sclerosis News Today.

B cell depletion works by.. Targeting Macrophages

How does B cell depletion work?….It seems in many different ways but notably it does not work by simply targeting B cells:-) Here it works by targeting msacrophages, which work by influencing…