US EditionStress Can Cause Eczema to Flare-up – Now We Know Why
Researchers found a specific nerve subset that activates eosinophils to worsen eczema under stress, suggesting new neuro-immune treatment targets, based on data from 51 patients.
- This week, researchers led by Jiahe Tian published in Science a study mapping a neural pathway linking stress to skin immune activation in a mouse model of atopic dermatitis.
- Faced with an unclear mechanism, Jiahe Tian and colleagues analyzed clinical data from 51 people with atopic dermatitis and mouse experiments, finding higher eosinophils linked to stress and disease severity.
- Laboratory experiments revealed that Pdyn+ noradrenergic sympathetic neurons release CCL11 signaling via CCR3 to recruit eosinophils, which activate through Adrb2 on eosinophils.
- Therapeutic implications include targeting the CCL11–CCR3 or Adrb2 pathways, as genetic removal of Pdyn+ neurons or eosinophil depletion halted stress-triggered inflammation, the authors suggest.
- Given that AD affects more than 200 million people worldwide, commentators caution that questions remain about other immune types and if similar mechanisms apply to psoriasis or inflammatory bowel disease.
12 Articles
12 Articles
Stress-activated pathway reveals how nervous system contributes to eczema flare-ups
The mystery of how stress exacerbates atopic dermatitis, more commonly known as eczema, may be closer to being understood. A new study published in the journal Science has identified a specific nerve pathway that helps explain the link.
Psychological stress can worsen outbreaks of atopic dermatitis and now a study describes in detail one of the biological routes behind that effect. The research, published in Science magazine, points out that a specific group of sympathetic neurons on active skin and attracts eosinophils, immune cells associated with inflammation, which intensifies skin lesions. The study is entitled A sympathetic-eosinophil axis orchesstrates psychologic stress…
Chinese researchers have discovered the network of neurons responsible for worsening the symptoms of atopic dermatitis in stressed people. An illustration of the dialogue maintained by our body with our emotionsAtopic dermatitis or eczema, the most common inflammatory skin disease, affects about 20% of children in Switzerland and 5% of adults. It is characterized by the appearance on the skin of red plaques and lesions, itching and dry epidermis…
Research carried out by a team from the Fudan University of China, top university of China, started by an analysis of over 50 people with eczema. Researchers compared the level of stress reported by participants with the severity of inflammation and eosinophiles – a type of white globe involved in inflammatory reactions – from blood and skin. The link between stress and eczemas showed a direct link: the higher levels of stress are associated wit…
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