US EditionChinese Scientists Use Stem Cells to Reverse Age-Related Stress in Monkeys
Engineered senescence-resistant stem cells reversed aging signs in elderly monkeys, improving memory, bone density, and reducing inflammation across 10 physiological systems, researchers reported.
- On May 5, 2025 the Cell paper reported engineered human stem cells reversed aging signs in elderly cynomolgus monkeys after a 44-week trial with biweekly SRC infusions.
- Researchers in Beijing engineered senescence-resistant mesenchymal progenitor cells by activating the FOXO3 gene, addressing aging as partly programmable and countering stem-cell repair decline.
- Single-Cell analyses revealed significant gene-expression reversals as treated macaques showed improved memory, maintained bone density, restored reproductive organs, and SRC-derived exosomes reduced senescent cells and inflammation.
- No immediate safety signals were observed in treated macaques, as the authors reported no tumors, tissue damage, or adverse effects and noted SRC therapies in people could treat aging.
- Amid debate, Dr. Josh Mitteldorf contends methylation clocks may conflate repair with harmful aging; he supported his view with analysis of a database of 278 individuals' Illumina 480K data published in Aging.
13 Articles
13 Articles
Restoring youth: Scientists use engineered cells to restore vitality in primates
Researchers from the Chinese Academy of Sciences and Capital Medical University utilized gene editing to create senescence-resistant human mesenchymal progenitor cells (SRCs). In a 44-week trial on aged macaques, biweekly intravenous SRC injections induced no adverse effects and spurred multi-system rejuvenation in 10 major physiological systems and 61 tissue types. Treated macaques displayed enhanced cognitive function and diminished age-relate…
Immortal Monkeys? Not Quite, But Scientists Just Reversed Aging With 'Super' Stem Cells - Nemos News Network
Immortal Monkeys? Not Quite, But Scientists Just Reversed Aging With ‘Super’ Stem Cells Key Points: “Super Stem Cells” boosted memory in monkeys and offered protection against neurodegeneration. They halted age-related bone loss and restored vitality in more than half of the 61 tissues examined. The therapy also cut back harmful inflammation and reduced the burden of senescent cells — the aged, non-dividing cells that drive aging throughout th…
Engineering Senescence-Resistant Stem Cells to Reverse Aging in Primates — Veritas Innovation
Discover how senescence-resistant human mesenchymal progenitor cells (SRCs), engineered to overexpress the longevity factor FOXO3, safely reversed aging markers across multiple tissues in aged macaques—offering a groundbreaking, multi‐system rejuvenation strategy for primates.
Coverage Details
Bias Distribution
- 50% of the sources are Center, 50% of the sources lean Right
Factuality
To view factuality data please Upgrade to Premium
