Convergent Evolution of Antibiotic Resistance Mechanisms Between Pyrrolobenzodiazepines and Albicidin in Multidrug Resistant Klebsiella Pneumoniae

Convergent evolution of antibiotic resistance mechanisms between pyrrolobenzodiazepines and albicidin in multidrug resistant Klebsiella pneumoniae

Pyrrolobenzodiazepines (PBDs) containing C8-linked aliphatic heterocycles have been developed as a new class of potent antibacterial compounds. They are active against multidrug resistant Gram-negative pathogens, including Klebsiella pneumoniae. When isolates were exposed to PBDs, they acquired resistance, with significant increases in inhibitory concentrations. Resistant strains showed mutations in genes associated with resistance to albicidin,…

Israeli Scientists’ Discovery Could Revolutionize Antibiotics

The team discovered protein fragments broken down by the proteasome were as effective in fighting microbes as antibiotics.

The First in 30 Years: Scientists Discover New Class of Antibiotics

Researchers have found a powerful new antibiotic candidate, lariocidin, that could combat drug-resistant bacteria and transform the fight against antimicrobial resistance. It has been nearly thirty years since a new class of antibiotics reached the market, but that could soon change. Researchers at McMaster University have made a breakthrough that could help turn the tide [...]