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Part of the genetic risk for schizophrenia acts through the placenta

Summary by Science Daily

An international team has identified associations between modifications in the placenta and the risk of developing schizophrenia, bipolar disorder, and major depression disorder.

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Science Daily

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Part of the genetic risk for schizophrenia acts through the placenta

An international team has identified associations between modifications in the placenta and the risk of developing schizophrenia, bipolar disorder, and major depression disorder.

10 days ago·United States

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Nature

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Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders

Increasing evidence supports the role of the placenta in neurodevelopment and in the onset of neuropsychiatric disorders. Recently, mQTL and iQTL maps have proven useful in understanding relationships between SNPs and GWAS that are not captured by eQTL. In this context, we propose that part of the genetic predisposition to complex neuropsychiatric disorders acts through placental DNA methylation. We construct a public placental cis-mQTL database…

10 days ago·United Kingdom

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Springer

Transactivation of elements in the human endogenous retrovirus W family by viral infection - Retrovirology

Aberrant expression of human endogenous retrovirus (HERV) elements in the W family has previously been associated with schizophrenia, multiple sclerosis and preeclampsia. Little is know regarding the basal expression, transcriptional regulation and functional significance of individual HERV-elements. Since viral infections have previously been reported to transactivate retroviral long terminal repeat regions we examined the basal expression of H…

10 days ago·United States

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researchsquare.com

Admixed gene expression models expand molecular and neurological insights into 6 major psychiatric disorders

Our understanding of the influence of ancestral background on genetically determined expression remains limited, especially when gene expression models are applied to studies from different or multiple populations. We performed transcriptome wide association studies (TWAS) in 6 different psych...

10 days ago

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Neuroscience News

Schizophrenia Risk May Begin in the Placenta

A new study highlights the placenta’s role in neuropsychiatric development, showing that DNA methylation influences gene expression tied to psychiatric disorders. Researchers found strong links between placental DNA methylation and conditions like schizophrenia, bipolar disorder, and major depression.

11 days ago

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