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Physics-Based Machine Learning for Subcellular Segmentation in Living Cells

Summary by Nature
Segmenting subcellular structures in living cells from fluorescence microscope images is a ground truth (GT)-deficient problem. The microscopes’ three-dimensional blurring function, finite optical resolution due to light diffraction, finite pixel resolution and the complex morphological manifestations of the structures all contribute to GT-hardness. Unsupervised segmentation approaches are quite inaccurate. Therefore, manual segmentation relying…

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University of Cambridge broke the news in on Friday, May 30, 2025.
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