Reactive Oligodendrocytes Promote Glioblastoma Progression through CCL5/CCR5-Mediated Glioma Stem Cell Maintenance

Reactive Oligodendrocytes Promote Glioblastoma Progression through CCL5/CCR5-Mediated Glioma Stem Cell Maintenance

Researchers utilized single-cell and spatial transcriptomics from primary and recurrent glioblastoma (GBM) tumors, immunohistochemistry, cytokine profiling, and migration assays to show that GBM cells recruit oligodendrocytes to the tumor border via fractalkine signaling. [Neuron] AbstractGraphical Abstract

Hijacked Helpers: Oligodendrocytes Emerge as Drivers of Glioblastoma Invasion

Glioblastoma (GBM) remains one of the most aggressive and lethal brain cancers, in large part because of its uncanny ability to infiltrate the brain far beyond the visible tumor mass. Even after maximal surgery, radiation, and chemotherapy, tumor cells often migrate along white matter tracts, seeding recurrence throughout the brain. A new study in Neuron now adds a surprising accomplice to this process: oligodendrocytes, the myelin-producing gli…