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Rakuten Medical's Anti-PD-L1 Antibody-IR700 Conjugate, RM-0256, Selected for AMED Funding

  • Rakuten Medical announced on June 4, 2025, that its RM-0256 photoimmunotherapy targeting PD-L1 received AMED funding in Japan.
  • The funding follows the urgent need for new treatments, as RM-0256 targets malignant epithelial tumors resistant to current therapies.
  • RM-0256 combines an anti-PD-L1 antibody and IRDye 700DX, a light-activated dye, to induce local and systemic antitumor effects via photoimmunotherapy.
  • Preclinical studies indicate RM-0256 activates a triple mechanism of action and may apply to multiple cancers, affecting roughly 22,000 patients annually in Japan.
  • AMED funding will support RM-0256's clinical development targeting unresectable and recurrent malignant epithelial tumors, aiming to expand treatment options.
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Rakuten Medical's Anti-PD-L1 Antibody-IR700 Conjugate, RM-0256, Selected for AMED Funding

AMED grant to support the clinical development of RM-0256 photoimmunotherapy for targeting malignant epithelial tumorsTargeting PD-L1, pre-clinical observations indicate RM-0256 harnesses a triple mechanism of action, with potential applications across a broad range of solid tumors, including melanoma, ocular melanoma,…

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Helena Independent Record broke the news in Helena, United States on Wednesday, June 4, 2025.
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