The structural diversity of psychedelic drug actions revealed

The structural diversity of psychedelic drug actions revealed

There is currently a resurgence in exploring the utility of classical psychedelics to treat depression, addiction, anxiety disorders, cluster headaches, and many other neuropsychiatric disorders. A biological target of these compounds, and a hypothesized target for their therapeutic actions, is the 5-HT2A serotonin receptor. Here, we present 7 cryo-EM structures covering all major compound classes of psychedelic and non-psychedelic agonists, inc…

Psychedelics Could Transform How We Sleep—Or If We Even Need It at All, New Theory Claims

Scientists are uncovering how psychedelics like LSD and DMT mimic REM sleep, raising questions about their potential to alter sleep cycles.

UFC Hall of Famer Claims Psychedelic Trip Cured Him of Fear of Heights

In a revealing conversation on the Area52 podcast, UFC legend Georges St-Pierre shared how an ayahuasca experience fundamentally changed him, including curing his lifelong fear of heights. The former UFC welterweight and middleweight champion opened up about his post-retirement journey into psychedelics, describing a profound out-of-body experience that altered his perception of consciousness and reality. “During Covid, after I retired, I d…

PT Neurons Hold the Secret to Psilocybin’s Mental Health Impact

Shrooms are not only about trippy visuals and euphoria vibes. These ‘magic mushrooms’ are also known for their amazing therapeutic promise. But have you ever wondered just what’s behind this hallucinogenic kick that you get from the shrooms?  Well, the star of this show is psilocybin, which is not present in all mushrooms but only in certain types. This active ingredient is what brings the ‘magic’ in ‘magic mushrooms,’ and it is gaining a lot of…

Do Psychedelics Heal Even Without Therapy?

Some say yes, others say not so much. Dive into the debate heating up in psychedelic medicine. [...] Read More... The post Do Psychedelics Heal Even Without Therapy? appeared first on DoubleBlind Mag.