US EditionSingle Birth Gene Therapy Yields Years-Long HIV Protection in Primates
AUSTRALIA, JUL 30 – Researchers found CD8 T-cell responses to conserved HIV peptides may help control viral rebound during treatment interruptions in 68 men with HIV, suggesting new vaccine targets.
- At the International AIDS Society Conference on HIV Science, data showed that IMAP-peptides were detected in 52%-100% of rebound HIV-1 sequences from participants in the PULSE trial of 68 men who have sex with men living with HIV.
- The IMAP analysis pipeline selected 182 peptides from structurally important and mutation-intolerant HIV-1 regions, building on prior findings linking CD8 T-cell responses to five conserved HIV regions.
- Among four noncontrollers and five transient controllers, IMAP-peptides appeared in 52%-100% of viral sequences across three ATIs, with CD8 T-cells showing a 15- to 53-fold higher effector response in transient controllers.
- The results underscore IMAP’s potential for informing new treatment strategies, prompting efforts to develop and test mRNA vaccine constructs containing IMAP-peptides to assess immune responses in people living with HIV.
- Looking ahead, the IMAP technique could be applied to other viruses, with future studies testing mRNA vaccine constructs in a humanized mouse model.
6 Articles
6 Articles
Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life
Despite advances in HIV-1 prophylaxis, vertical transmission remains a pressing problem in developing countries1. Given the promise of broadly neutralizing antibodies (bNAbs) for HIV-1 prevention2, we hypothesized that neonatal delivery of bNAbs using adeno-associated virus (AAV) could provide durable HIV-1 immunity during infancy. Here, using infant rhesus macaques (Macaca mulatta) as a model, we show that a one-time administration of an AAV ve…
'One and done': A single shot at birth may shield children from HIV for years
A new study in Nature shows that delivering a single injection of gene therapy at birth may offer years-long protection against HIV, tapping into a critical window in early life that could reshape the fight against pediatric infections in high-risk regions.
Medscape
Anti-Aging, Acupuncture and Health NewsNovel Peptides Expressed in HIV Could Drive Treatment
Findings could support new vaccine development to mitigate rapid virus mutation. Medscape Medical News
Coverage Details
Bias Distribution
- 67% of the sources are Center
Factuality
To view factuality data please Upgrade to Premium
