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No link between Tylenol use in pregnancy and autism or ADHD, new study finds

A review of 43 studies using sibling comparisons found no strong evidence linking prenatal paracetamol use to autism, ADHD, or intellectual disabilities, supporting current medical guidelines.

  • Published Friday, a major meta-analysis pooling about 60 studies found that acetaminophen taken as directed in pregnancy is not linked to autism, ADHD or intellectual disability.
  • Earlier studies showed mixed results, leaving pregnant people unsure about acetaminophen safety as study authors noted symptoms like fever, infection, pain and inflammation may confound links to fetal brain development.
  • Focusing on sibling-comparison designs, the review emphasized studies comparing siblings with and without prenatal acetaminophen exposure and included follow-up longer than five years.
  • Study authors and clinicians said pregnant women should feel reassured that acetaminophen remains the recommended first-line option for pain or fever in pregnancy when used as directed, and ACOG advises the lowest effective dose for the shortest time with care for persistent or high fever.
  • Voices outside the study cautioned or criticized, including an HHS official who said it "does not resolve an important public health question; it sidesteps it," while President Donald Trump and the FDA debated acetaminophen's safety and Kenvue defended Tylenol.
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Paracetamol during pregnancy is safe and does not affect the neurological development of children. An exhaustive review published in The Lancet disassembles the doubts sown by the Trump administration and concludes, with solid evidence, that this drug does not increase the risk of autism, ADHD or intellectual disability. Research is a meta-analysis of 43 studies that provides solid evidence that the use of paracetamol during pregnancy is safe an…

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Science Daily broke the news in United States on Friday, January 16, 2026.
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