US EditionAssessing the Impact of mRNA Vaccination in Chronic Inflammatory Murine Model
3 Articles
3 Articles
Assessing the impact of mRNA vaccination in chronic inflammatory murine model
The implications of administration of mRNA vaccines to individuals with chronic inflammatory diseases, including myocarditis, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), are unclear. We investigated mRNA vaccine effects in a chronic inflammation mouse model implanted with an LPS pump, focusing on toxicity and immunogenicity. Under chronic inflammation, mRNA vaccines exacerbated cardiac damage and myocarditis, inducing mild h…
Lifesaving rheumatoid arthritis vaccine could transform treatment worldwide
Rheumatoid arthritis is a painful and disabling autoimmune disease that affects more than 1% of people worldwide. In the United States alone, it disrupts the lives of about 1.3 million people. The disease begins when the immune system wrongly attacks healthy tissues, especially the joints, causing swelling, stiffness, and lasting pain. As it progresses, it can make even simple movements difficult, taking a serious toll on daily life. While treat…
The study, published in eLife magazine, shows that RAS-p110α-mediated signaling in macrophages is crucial for both the onset and effective resolution of inflammation. Macrophages are essential immune cells that act as the first line of defense against infections and tissue damage. Their function goes beyond the simple elimination of pathogens: they also coordinate tissue repair and resolution of inflammation to avoid chronic damage in the organi…
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