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Smart Microscope Captures Aggregation of Misfolded Proteins

Summary by myscience.org
24.07.2025 - Researchers have developed a 'self-driving' microscope that can predict the onset of misfolded protein aggregation - a hallmark of neurodegenerative disease - as well as analyze the biomechanical properties of these aggregates.
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Until today, the skin, brain and all the tissues of the human body were difficult to observe in detail with an optical microscope, because the contrast of the image was hindered by the high density of their structures. The research group of the laboratory of microscopy and molecular spectroscopy at the Istituto italiano di Tecnologia [...]

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An international team led by the University Hospital Hamburg-Eppendorf (UKE) has developed a new method for the high-resolution analysis of tissue samples. With the method "Pathology-Oriented MultiPlexing (PathoPlex)" more than 100 different proteins can be used simultaneously in a...

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bionity.com broke the news in on Thursday, July 24, 2025.
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