New genetic reference map accelerates human stem cell research

New genetic reference map accelerates human stem cell research

A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells.

New CRISPR Atlas Details How Every Gene Influences Stem Cells

A team led by bioengineers at the University of California San Diego has developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells.

Genome-Scale CRISPRi Atlas Maps Gene Function Across Human iPSCs

A new genome-scale atlas is offering an unprecedented look at how individual genes shape the transcriptional landscape of human induced pluripotent stem cells (iPSCs). Published in Nature Biotechnology, the resource catalogs the effects of perturbing 11,692 expressed genes across more than 2.5 million single cells, creating a reference framework for understanding how pluripotent identity is maintained and regulated. The study is titled, “A genom…

Open-Access Genetic Map Provides Reference for What Almost Every Stem Cell Gene Does

Researchers have developed a genome-scale reference map that details how individual genes control the functions and identities of human stem cells. This open-access resource could help researchers build virtual cell models for complex diseases, as well as design patient-specific treatments for these diseases.