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New Discovery Reveals Dopamine Operates with Surgical Precision, Not as a Broad Signal

ARAPAHOE COUNTY, COLORADO, JUL 10 – Researchers found dopamine transmits in rapid, localized bursts, challenging old beliefs and offering new directions for treating disorders like Parkinson's and ADHD.

  • Published today in Science, researchers at the University of Colorado Anschutz Medical Campus found dopamine acts like a finely-tuned postal service, delivering highly localized messages in the brain.
  • Long accepted as a broad diffusion system, dopamine’s role is now questioned, overturning a century-old view, as scientists previously believed.
  • Advanced microscopy revealed dopamine’s pinpoint release, showing it occurs in concentrated hotspots enabling targeted, rapid responses in nearby brain cells.
  • As a result, treatment approaches could shift, since current treatments focus on restoring overall dopamine levels, and understanding dopamine's 'precision signaling' could improve therapies for dopamine-related disorders.
  • Future studies will examine how precision signaling varies, with Christopher Ford, PhD, noting more work is needed to understand disease-specific dopamine signaling changes in neurological and psychiatric diseases.
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New Discovery Reveals Dopamine Operates with Surgical Precision, Not as a Broad Signal

New understanding of how dopamine acts could reshape how brain disorders are treated

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Medical Xpress broke the news in on Thursday, July 10, 2025.
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