Activation of D1R/PKA/mTOR Signaling Cascade in Medial Prefrontal Cortex Underlying the Antidepressant Effects of L-SPD

Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD

Major depressive disorder (MDD) is a common neuropsychiatric disorder characterized by diverse symptoms. Although several antidepressants can influence dopamine system in the medial prefrontal cortex (mPFC), but the role of D1R or D2R subtypes of dopamine receptor during anti-depression process is still vague in PFC region. To address this question, we investigate the antidepressant effect of levo-stepholidine (l-SPD), an antipsychotic medicatio…

Advanced microscopy reveals that dopamine operates with surgical precision, not as a broad signal

A new study from the University of Colorado Anschutz Medical Campus has upended decades of neuroscience dogma, revealing that dopamine, a neurotransmitter critical for movement, motivation, learning and mood, communicates in the brain with extraordinary precision, not broad diffusion as previously believed. This groundbreaking research offers fresh hope for millions of people living with dopamine-related disorders, marking a significant advance …

Hitting the Right Target – SFU Study Sheds Light on How Drug Used To Treat Parkinson’s Disease Affects the Brain - Science in Vancouver

The new study, published in the journal Movement Disorders, looks at why levodopa – the main drug used in dopamine replacement therapy – is sometimes less effective in patients. The drug is typically prescribed to help reduce the movement symptoms associated with the neurodegenerative disorder. While it is effective in improving symptoms for the vast majority of patients, not everyone experiences the same level of benefit. In order to find out w…

Brain breakthrough: Dopamine doesn't work at all like we thought it did

Dopamine doesn’t flood the brain as once believed – it fires in exact, ultra-fast bursts that target specific neurons. The discovery turns a century-old view of dopamine on its head and could transform how we treat everything from attention-deficit/hyperactivity disorder (ADHD) to Parkinson’s disease.Continue ReadingCategory: Mental Health, Brain Health, Body & MindTags: University of Colorado, ADHD, neurodiversity, neurons, Parkinson's Disease,…

Dopamine Acts Locally, Not Globally

New research has overturned decades of belief about how dopamine communicates in the brain, showing it acts with pinpoint precision rather than broad diffusion. Scientists discovered that dopamine is released in localized hotspots, allowing highly specific and timely messages to nerve cell branches.

New Discovery Reveals Dopamine Operates with Surgical Precision, Not as a Broad Signal

A new study from the University of Colorado Anschutz Medical Campus has upended decades of neuroscience dogma, revealing that dopamine, a neurotransmitter critical for movement, motivation, learning and mood, communicates in the brain with extraordinary precision, not broad diffusion as previously believed. This groundbreaking research offers fresh hope for millions of people living with dopamine-related disorders, marking a significant advance …