The Secretome of Senescent Monocytes Predicts Age-Related Clinical Outcomes in Humans

The secretome of senescent monocytes predicts age-related clinical outcomes in humans

Cellular senescence increases with age and contributes to age-related declines and pathologies. We identified circulating biomarkers of senescence and related them to clinical traits in humans to facilitate future noninvasive assessment of individual senescence burden, and efficacy testing of novel senotherapeutics. Using a nanoparticle-based proteomic workflow, we profiled the senescence-associated secretory phenotype (SASP) in THP-1 monocytes …

A new blood-based epigenetic clock for aging focuses on intrinsic capacity

A team of international researchers has developed a new biological age "clock" that estimates how well someone is aging, not just how "old" they or their various organs might be. The IC Clock, which is described in a study in Nature Aging, measures intrinsic capacity (IC), the sum of six key functions that determine healthy aging: mobility, cognition, mental health, vision, hearing and nutrition/vitality.

UC Davis Graduate To Research Aging Solutions

A UC Davis graduate from San Jose is set to transform the understanding and experience of aging through groundbreaking research and compassionate community service. Avantika Gokulnatha, recipient of the prestigious University Medal at this year’s commencement, has dedicated her undergraduate journey to addressing the challenges of aging through scientific research, technological support for seniors, and medical volunteerism. Gokulnatha’s passion…

New Blood-Based Epigenetic Clock Revolutionizes Aging Research by Targeting

A groundbreaking advancement in the science of aging has emerged from an international collaboration of researchers who have developed a sophisticated biological age “clock” known as the Intrinsic Capacity (IC) Clock. Unlike conventional aging clocks that primarily estimate chronological or organ-specific age, the IC Clock innovatively measures the overall functional capacity involved in the aging process. This novel clock, recently detailed in …