Let-7 gene is a key guardian of healthy lungs that keeps pulmonary fibrosis in check, study finds

Let-7 gene is a key guardian of healthy lungs that keeps pulmonary fibrosis in check, study finds

Researchers at Baylor College of Medicine and collaborating institutions have uncovered a key molecular player that is involved in lung repair and in the development of pulmonary fibrosis, a common and severe class of adult lung diseases linked to respiratory failure.

Tumor suppressor microRNA prevents lung scarring, study finds

Let-7, an established tumor suppressor microRNA, plays a key role in lung tissue repair and the development of scarring, a study found.

Let-7 Restrains an Epigenetic Circuit in AT2 Cells to Prevent Fibrogenic Intermediates in Pulmonary Fibrosis

The authors demonstrated that the let-7 miRNA family plays a homeostatic role in alveolar type 2 (AT2) quiescence by preventing the uncontrolled accumulation of AT2 transitional cells and promoting AT1 differentiation. [Nature Communications] Full Article