Large-Scale LNP Process Conversions: The many hurdles of LNP scale-up and what to consider

Large-Scale LNP Process Conversions: The many hurdles of LNP scale-up and what to consider

Lipid nanoparticle (LNP) formulation development begins on a small scale, often with homemade or benchtop setups, using syringe pumps and easily accessible micro-mixing systems. Once a promising formulation has been identified, the next step is to transition to standardized large-scale impingement mixing systems, such as the high flow T-mixing pumps that were used to produce the COVID-19 vaccines (Sealy 2021). Formulators need to consider a numb…