US EditionJCI What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
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JCI What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is composed of a dense stromal compartment and is poorly vascularized, resulting in limited nutrient delivery. As a result, PDAC cells must adapt to cope with the metabolic stresses brought on by TME nutrient limitation. In this article, we first review recent studies that have provided quantitative measurements of nutrient levels in the PDAC TME. These studies have prov…
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