US EditionJCI The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
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JCI The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
Purine nucleotides are critical for nucleic acid synthesis, signaling, and cellular metabolism. Thiopurines (TPs), including 6-mercaptopurine and 6-thioguanine, are cornerstone agents for the treatment of acute lymphoblastic leukemia (ALL). TP efficacy and cytotoxicity depend on the metabolism and intracellular activation of TPs, a process influenced by pharmacogenes such as thiopurine-S methyltransferase (TPMT) and NUDIX (nucleoside diphosphate…
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