JCI Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation

JCI Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation

Although mammals generally demonstrate limited regenerative capacity compared with amphibians, the digit tip retains remarkable regenerative potential, providing a useful model to study successful mammalian regeneration. This process involves coordinated immune cell activity, vascular remodeling, and tissue reconstruction, yet the molecular checkpoints controlling regenerative versus fibrotic outcomes remain poorly understood. In mammals, regene…