US EditionJCI Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention
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JCI Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention
Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal cancers, with metastasis as the primary driver of mortality. While metastatic mechanisms are shared across malignancies, PDAC metastasis poses unique therapeutic challenges due to the presence of extensive tumor heterogeneity, desmoplasia, and immunosuppression — features that enable diverse migratory behaviors and therapeutic resistance. Recent advances have shown that metast…
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