US EditionJCI LAG3 regulates antibody responses in a murine model of kidney transplantation
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JCI LAG3 regulates antibody responses in a murine model of kidney transplantation
Lymphocyte activation gene 3 (LAG3) is a coinhibitory receptor expressed by various immune cells. Although the immunomodulatory potential of LAG3 is being explored in cancer and autoimmunity, there is no information on its role after organ transplantation. Our study investigated the functions of LAG3 in a mouse model of renal allograft rejection. LAG3–/– recipients rapidly rejected MHC-mismatched renal allografts that were spontaneously accepted…
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