JCI Human genetics of metabolic dysfunction–associated steatotic liver disease: from variants to cause to precision treatment

JCI Human genetics of metabolic dysfunction–associated steatotic liver disease: from variants to cause to precision treatment

Metabolic dysfunction–associated steatotic liver disease (MASLD) is characterized by increased hepatic steatosis with cardiometabolic disease and is a leading cause of advanced liver disease. We review here the genetic basis of MASLD. The genetic variants most consistently associated with hepatic steatosis implicate genes involved in lipoprotein input or output, glucose metabolism, adiposity/fat distribution, insulin resistance, or mitochondrial…