JCI Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection

JCI Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection

Graft endothelial cells (ECs) express donor alloantigens and encounter cytotoxic T lymphocytes (CTLs) but are generally spared during T cell–mediated rejection (TCMR), which predominantly affects epithelial structures. The mechanisms underlying this vascular immune privilege are unclear. Transcriptomics analyses and endothelial-mesenchymal transition assessments confirmed that the graft endothelium was preserved during TCMR. Coculture experiment…