Structure of human drug transporters OATP1B1 and OATP1B3

Structure of human drug transporters OATP1B1 and OATP1B3

The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary excretion, a key step in drug elimination from the human body. Polymorphic variants of these transporters can cause reduced drug clearance and adverse drug effects such as statin-induced rhabdomyolysis, and co-administration of OATP substrates can lead to damaging drug-drug inter…

Bile imbalance linked to liver cancer: Key molecular switch sheds new light on treatment interventions

A new study reveals how a critical imbalance in bile acids—the substances made by the liver that help digest fats—can trigger liver diseases, including hepatocellular carcinoma (HCC), the most common form of liver cancer. By identifying a key molecular switch that regulates bile, the study sheds new light on potential liver cancer treatment.

Solute Carrier Family 2 Member 2 (Glucose Transporter 2): A Common Factor of Hepatocyte and Hepatocellular Carcinoma Differentiation

Scientists investigated SLC2A2’s role in liver differentiation using in silico, in vitro, and in vivo approaches. [PLOS One] Full Article

Inflammation Markers Predict Hepatectomy Patient Outcomes

In a groundbreaking development within oncology and immunology, researchers have unveiled a novel prognostic model that leverages inflammation-based biomarkers to predict the outcomes of patients suffering from hepatocellular carcinoma (HCC) who undergo radical hepatectomy. This innovative approach combines the C-reactive protein to albumin ratio (CAR) with the Systemic Inflammatory Response Index (SIRI), two critical indicators of the body’s in…