3 Articles
3 Articles
JCI Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models
The N-Myc gene MYCN amplification accounts for the most common genetic aberration in neuroblastoma and strongly predicts the aggressive progression and poor clinical prognosis. However, clinically effective therapies that directly target N-Myc activity are limited. N-Myc is a transcription factor, and its stability is tightly controlled by ubiquitination-dependent proteasomal degradation. Here, we discovered that Kelch-like protein 37 (KLHL37) p…
India Marks Breakthrough in Cancer Care: Tata Memorial Pioneers High-Dose MIBG Therapy - PUNE PULSE
In a landmark development for cancer treatment in India, Mumbai’s Tata Memorial Centre has become the first hospital in the country to successfully deliver high-dose MIBG therapy — a targeted nuclear medicine technique crucial in treating neuroblastoma, a rare and aggressive childhood cancer. The breakthrough treatment was administered on May 5, 2025, at Tata Memorial’s
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