US EditionFIRST ON CNN: Fighting Early-Stage Alzheimer’s with Intensive Lifestyles Changes Works, Study Finds
UNITED STATES, JUL 28 – The U.S. POINTER trial enrolled over 2,100 older adults at risk for dementia and found structured lifestyle changes delayed cognitive decline by up to two years, researchers said.
- Dr. Dean Ornish presented a 2024 study update showing that a 40-week intensive lifestyle program improved cognition in early-stage Alzheimer's patients in Toronto.
- The program consisted of a plant-based diet, regular aerobic workouts every day, techniques for managing stress, and group support aimed at lowering amyloid levels, which are associated with Alzheimer's disease.
- Among 26 participants, 46% improved in three of four cognitive tests, 37.5% showed no decline, and blood tests showed amyloid levels retreating in some individuals.
- Dr. Ornish stated a dose-response relationship between lifestyle adherence and cognitive improvement with no side effects, while experts noted some Alzheimer's markers did not change significantly.
- These findings offer new hope that intensive lifestyle changes may slow or reverse Alzheimer’s progression, though Ornish emphasized the need for replication in larger, diverse groups.
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17 Articles
Can lifestyle changes protect the brain from Alzheimer’s? A new study offers hope for prevention. - The Boston Globe
A nutritious diet, and socializing, can improve cognitive performance in people at risk for dementia, researchers found in a $50 million new study.
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Structured lifestyle program improves cognition in at-risk older adults
The Alzheimer's Association U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) found that certain lifestyle interventions improved cognition in older adults at risk of cognitive decline. U.S. POINTER is a two-year, multi-site clinical trial, one of which is the Baylor College of Medicine's Alzheimer's Disease and Movement Disorder Center, testing two different lifestyle interventions in a representati…
FROM THE ALZHEIMER’S ASSOCIATION INTERNATIONAL CONFERENCE 2025: U.S. POINTER STUDY SHOWS STRUCTURED LIFESTYLE PROGRAM TARGETING MULTIPLE RISK FACTORS IMPROVES COGNITION IN OLDER ADULTS AT RISK OF COGNITIVE DECLINE
Key Takeaways Two lifestyle interventions in U.S. POINTER improved cognition in older adults at risk of cognitive decline. A structured intervention with more support and accountability showed greater improvement compared to a self-guided intervention. In a large, representative group of older adults at high risk for cognitive decline, multidomain lifestyle interventions were delivered with high […] The post FROM THE ALZHEIMER’S ASSOCIATION INTE…
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