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How Cannabis Makes THC, CBD, and CBC, Explained

Summary by Vice
For a plant that humans have been cultivating, smoking, weaving, eating, and arguing about for thousands of years, cannabis still keeps a surprising amount of its history locked away at the molecular level. A new study just cracked part of that vault open by resurrecting enzymes that went extinct millions of years ago, revealing how cannabis learned to make THC, CBD, and CBC in the first place. The research, led by scientists at Wageningen Unive…

3 Articles

Cannabis produces more than 120 cannabinoids, some of which are of increasing therapeutic interest. While THC and CBD are now well known, other compounds, such as cannabichromene (CBC), remain difficult to study due to lack of availability in sufficient quantities. This limitation is due in part to the still poorly understood functioning of enzymes that allow the plant to synthesize these molecules. For the first time, a team of researchers at W…

An ancient cannabis enzyme, active millions of years ago in the ancestors of modern plants, has been returned to life thanks to a technique that allowed to reconstruct the ancestral sequence of the gene responsible for its production. This achievement is the work of a group of researchers from the University of Wageningen (Netherlands), [...] The entry "Reviven" a cannabis enzyme of millions of years was first published in Information Focus.

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Vice broke the news in New York, United States on Tuesday, January 13, 2026.
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