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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Summary by Nature
Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to enhancing regeneration is to increase the axonal supply of growth molecules and organelles. We achieved this by expressing the adaptor molecule Protrudin which is normally found at low levels in non-regenerative neurons. Elevated Protrudin expression enabled robust central nervous system regener…

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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to enhancing regeneration is to increase the axonal supply of growth molecules and organelles. We achieved this by expressing the adaptor molecule Protrudin which is normally found at low levels in non-regenerative neurons. Elevated Protrudin expression enabled robust central nervous system regener…

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Medical XpressMedical Xpress

Innovative model shows how optic tract injuries can heal through axonal rewiring

A research team has established an innovative intracranial pre-olivary pretectal nucleus (OPN) optic tract injury model (pre-OPN OTI), shedding light on crucial mechanisms of functional axonal rewiring following central nervous system injury. The team was led by Prof. Liu Kai from the Division of Life Science and Department of Chemical and Biological Engineering at the Hong Kong University of Science and Technology (HKUST).

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hkust.edu.hkhkust.edu.hk

HKUST Life Science Researchers Establish an Intracranial Optic Tract Injury Model to Reveal Mechanisms of Functional Circuit Reconstruction Following CNS Injury

HKUST Life Science Researchers Establish an Intracranial Optic Tract Injury Model to Reveal Mechanisms of Functional Circuit Reconstruction Following CNS Injury - Preview Anonymous (not verified) Fri, 03/28/2025 - 12:09 A research team led by Prof. LIU Kai from the Division of Life Science and Department of Chemical and Biological Engineering at the Hong Kong University of Science and Technology (HKUST) has established an innovative intracranial…

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hkust.edu.hk broke the news in on Friday, March 28, 2025.
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